Techniques in Regional Anesthesia & Pain Management
Volume 11, Issue 1 , Pages 9-18 , January 2007

DepoDur® (extended-release epidural morphine): a review of an old drug in a new vehicle

  • Pamela C. Nagle, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Pamela C Nagle, MD, Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Blvd., Winston Salem, NC 27157.
    • ,
  • J.C. Gerancher, MD

References 

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  2. Burstal R, Wegener F, Hayes C, et al. Epidural analgesia: prospective audit of 1062 patients. Anaest Intensive Care. 1998;26:165–172
  3. Horlocker TT, Wedel DJ, Benzon H, et al. Regional anesthesia in the anticoagulated patient: defining the risks. Reg Anesth Pain Med. 2003;28:172–197
  4. Rowlingson JC, Hanson PB. Neuraxial anesthesia and low-molecular weight heparin prophylaxis in major orthopedic surgery in the wake of the latest American Society of Regional Anesthesia guidelines. Anesth Analg. 2005;100:1482–1488
  5. Viscusi ER. Emerging techniques in the management of acute pain: epidural analgesia. Anesth Analg. 2005;101:S23–S29
  6. Howell SB. Cinical applications of a novel sustained-release injectable drug delivery system: DepoFoam technology. Cancer J. 2001;7:219–227
  7. SkyePharma: Photos on file. Available at: http://www.skyepharma.com. Accessed January 15, 2007
  8. Angst MS, Drover DR. Pharmacology of drugs formulated with DepoFoam™: a sustained release drug delivery system for parenteral administration using multivesicular liposome technology. Clin Pharmacokinet. 2006;45:1153–1176
  9. Kim T, Murdande S, Gruber A, et al. Sustained-release morphine for epidural analgesia in rats. Anesthesiology. 1996;85:331–338
  10. Yaksh TL, Provencher JC, Rathburn ML, et al. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs. Anesthesiology. 1999;90:1402–1412
  11. Endo Pharmaceuticals, Inc: Prescribing Information (package insert). Chadds Ford, PA, 2004
  12. Gambling D, Hughes T, Gould E, et al. A pharmacokinetic and pharmacodynamic study of a single dose of epidural DepoDur following epidural bupivicaine: a randomized controlled trial in patients undergoing lower abdominal surgery. Reg Anesth Pain Med. 2005;30:A29
  13. Viscusi ER, Kopacz D, Hartrick C, et al. Single-dose extended-release epidural morphine for pain following hip arthroplasty. Am J Ther. 2006;13:423–431
  14. Viscusi ER, Martin G, Hartrick CT, et al. Forty-eight hours of postoperative pain relief after total hip arthroplasty with a novel, extended-release epidural morphine formulation. Anesthesiology. 2005;102:1014–1022
  15. Hartrick CT, Martin G, Kantor G, et al. Evaluation of single-dose extended-release epidural morphine formulation for pain after knee arthroplasty. J Bone Joint Surg. 2006;88-A:271–281
  16. Gambling D, Hughes T, Martin G, et al. A comparison of DepoDur,™ a novel, single-dose extended-release epidural morphine, with standard epidural morphine for pain relief after lower abdominal surgery. Anesth Analg. 2005;100:1065–1074
  17. Carvalho B, Riley E, Cohen SE, et al. Single-dose, sustained-release epidural morphine in the management of postoperative pain after elective cesarean section: results of a multicenter randomized controlled study. Anesth Analg. 2005;100:1150–1158
  18. Roland L, Campitelli V, Chu L, et al. Extended-release epidural morphine compared to standard epidural morphine for post-cesarean pain. Anesthesiology. 2006;105:A761
  19. Viscusi E. Extended-release epidural morphine formulation data far from clear (In reply). Anesthesiology. 2005;103:1318–1319
  20. Cohen J. The t test for means. In:  Cohen J editors. Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: Lawrence Erlbaum Assoc; 1988;p. 19–74
  21. Data to be presented as an abstract at the Annual American Society of Regional Anesthesia (ASRA) Meeting in Vancouver, British Columbia, April 2007
  22. Boezaart AP. Evaluation of single-dose, extended-release epidural morphine formulation for pain after knee arthroplasty. J Bone Joint Surg. 2006;88-A:2535–2536
  23. Tulchinsky A. Reader calls for fair risk-benefit analyses. Anesth Patient Safety Foundation Newsletter. 2005;20:84

PII: S1084-208X(07)00012-2

doi: 10.1053/j.trap.2007.02.011

Techniques in Regional Anesthesia & Pain Management
Volume 11, Issue 1 , Pages 9-18 , January 2007

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