Techniques in Regional Anesthesia & Pain Management
Volume 11, Issue 3 , Pages 164-170 , July 2007

Complications of vertebroplasty and kyphoplasty

  • Yin C. Hu, MD
  • ,
  • David J. Hart, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: David J. Hart, MD, The Neurological Institute, Department of Neurological Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106.

References 

  1. Report, N.O.F.N.P: America’s bone health: the state of osteoporosis and low bone mass. 2002;Available from: http://www.nof.org/advocacy/prevalence. Accessed September 10, 2006
  2. Kan SH, Frye MA, et al. Epidemiology of vertebral fractures in women. LJ III Am J Epidemiol. 1989;129:1000–1011
  3. Kado DM, Duong T, Stone KL, et al. Incident vertebral fractures and mortality in older women: a prospective study. Osteoporos Int. 2003;14:589–594
  4. Kado DM, Browner WS, Palermo L, et al. Vertebral fractures and mortality in older women: a prospective study (Study of Osteoporotic Fractures Research Group). Arch Intern Med. 1999;159:1215–1220
  5. Leech JA, Dulberg C, Kellie S, et al. Relationship of lung function to severity of osteoporosis in women. Am Rev Respir Dis. 1990;141:68–71
  6. Silverman SL. The clinical consequences of vertebral compression fracture. Bone. 1992;13(suppl 2):S27–S31
  7. Grados F, Depriester C, Cayrolle G, et al. Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Rheumatology (Oxford). 2000;39:1410–1414
  8. Jensen ME, Evans AJ, Mathis JM, et al. Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. AJNR Am J Neuroradiol. 1997;18:1897–1904
  9. Hulme PA, Krebs J, Ferguson SJ, et al. Vertebroplasty and kyphoplasty: a systematic review of 69 clinical studies. Spine. 2006;31:1983–2001
  10. Atalay B, Caner H, Gokce C, et al. Kyphoplasty: 2 years of experience in a neurosurgery department. Surg Neurol. 2005;64(suppl 2):S72–S76
  11. Ledlie JT, Renfro MB. Kyphoplasty treatment of vertebral fractures: 2-year outcomes show sustained benefits. Spine. 2006;31:57–64
  12. Zoarski GH, Snow P, Olan WJ, et al. Percutaneous vertebroplasty for osteoporotic compression fractures: quantitative prospective evaluation of long-term outcomes. J Vasc Interv Radiol. 2002;13:139–148
  13. Barr JD, Barr MS, Lemley TJ, et al. Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine. 2000;25:923–928
  14. Evans AJ, Jensen ME, Kip KE, et al. Vertebral compression fractures: pain reduction and improvement in functional mobility after percutaneous polymethylmethacrylate vertebroplasty retrospective report of 245 cases. Radiology. 2003;226:366–372
  15. Galibert P, Deramond H, Rosat P, et al. [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]. Neurochirurgie. 1987;33:166–168
  16. Weill A, Chiras J, Simon JM, et al. Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement. Radiology. 1996;199:241–247
  17. Phillips FM, Todd Wetzel F, Lieberman I. An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty. Spine. 2002;27:2173–2178discussion 2178-2179
  18. Francois K, Taeymans Y, Poffyn B, et al. Successful management of a large pulmonary cement embolus after percutaneous vertebroplasty: a case report. Spine. 2003;28:E424–E425
  19. Padovani B, Kasriel O, Brunner P, et al. Pulmonary embolism caused by acrylic cement: a rare complication of percutaneous vertebroplasty. AJNR Am J Neuroradiol. 1999;20:375–377
  20. Jang JS, Lee SH, Jung SK. Pulmonary embolism of polymethylmethacrylate after percutaneous vertebroplasty: a report of three cases. Spine. 2002;27:E416–E418
  21. Tozzi P, Abdelmoumene Y, Corno AF, et al. Management of pulmonary embolism during acrylic vertebroplasty. Ann Thorac Surg. 2002;74:1706–1708
  22. Freitag M, Gottschalk A, Schuster M, et al. Pulmonary embolism caused by polymethylmethacrylate during percutaneous vertebroplasty in orthopaedic surgery. Acta Anaesthesiol Scand. 2006;50:248–251
  23. Syed MI, Jan S, Patel NA, et al. Fatal fat embolism after vertebroplasty: identification of the high-risk patient. AJNR Am J Neuroradiol. 2006;27:343–345
  24. Yoo KY, Jeong SW, Yoon W, et al. Acute respiratory distress syndrome associated with pulmonary cement embolism following percutaneous vertebroplasty with polymethylmethacrylate. Spine. 2004;29:E294–E297
  25. Monticelli F, Meyer HJ, Tutsch-Bauer E. Fatal pulmonary cement embolism following percutaneous vertebroplasty (PVP). Forensic Sci Int. 2005;149:35–38
  26. Scroop R, Eskridge J, Britz GW. Paradoxical cerebral arterial embolization of cement during intraoperative vertebroplasty: case report. AJNR Am J Neuroradiol. 2002;23:868–870
  27. Chen YJ, Tan TS, Chen WH, et al. Intradural cement leakage: a devastatingly rare complication of vertebroplasty. Spine. 2006;31:E379–E382
  28. Tsai TT, Chen WJ, Lai PL, et al. Polymethylmethacrylate cement dislodgment following percutaneous vertebroplasty: a case report. Spine. 2003;28:E457–E460
  29. Shapiro S, Abel T, Purvines S. Surgical removal of epidural and intradural polymethylmethacrylate extravasation complicating percutaneous vertebroplasty for an osteoporotic lumbar compression fracture (Case report). J Neurosurg. 2003;98:90–92
  30. Lee BJ, Lee SR, Yoo TY. Paraplegia as a complication of percutaneous vertebroplasty with polymethylmethacrylate: a case report. Spine. 2002;27:E419–E422
  31. Harrington KD. Major neurological complications following percutaneous vertebroplasty with polymethylmethacrylate: a case report. J Bone Joint Surg Am. 2001;83A:1070–1073
  32. Lopes NM, Lopes VK. Paraplegia complicating percutaneous vertebroplasty for osteoporotic vertebral fracture: case report. Ar Qneuropsiquiatr. 2004;62:879–881
  33. Schmid KE, Boszczyk BM, Bierschneider M, et al. Spondylitis following vertebroplasty: a case report. Eur Spine J. 2005;14:895–899
  34. Yu SW, Chen WJ, Lin WC, et al. Serious pyogenic spondylitis following vertebroplasty: a case report. Spine. 2004;29:E209–E211
  35. Walker DH, Mummaneni P, Rodts GE. Infected vertebroplasty (Report of two cases and review of the literature). Neurosurg Focus. 2004;17:E6
  36. Alfonso Olmos M, Silva Gonzalez A, Duart Clemente J. Infected vertebroplasty due to uncommon bacteria solved surgically: a rare and threatening life complication of a common procedure: report of a case and a review of the literature. Spine. 2006;31:E770–E773
  37. Mummaneni PV, Walker DH, Mizuno J, et al. Infected vertebroplasty requiring 360 degrees spinal reconstruction: long-term follow-up review (Report of two cases). J Neurosurg Spine. 2006;5:86–89
  38. Vats HS, McKiernan FE. Infected vertebroplasty: case report and review of literature. Spine. 2006;31:E859–E862
  39. Phillips H, Cole PV, Lettin AW. Cardiovascular effects of implanted acrylic bone cement. Br Med J. 1971;3:460–461
  40. Duncan JA. Intra-operative collapse or death related to the use of acrylic cement in hip surgery. Anaesthesia. 1989;44:149–153
  41. Modig J, Busch C, Olerud S, et al. Arterial hypotension and hypoxaemia during total hip replacement: the importance of thromboplastic products, fat embolism and acrylic monomers. Acta Anaesthesiol Scand. 1975;19:28–43
  42. Ellis RH, Mulvein J. The cardiovascular effects of methylmethacrylate. J Bone Joint Surg Br. 1974;56:59–61
  43. Lin EP, Ekholm S, Hiwatashi A, et al. Vertebroplasty: cement leakage into the disc increases the risk of new fracture of adjacent vertebral body. AJNR Am J Neuroradiol. 2004;25:175–180
  44. Trout AT, Kallmes DF, Kaufmann TJ. New fractures after vertebroplasty: adjacent fractures occur significantly sooner. AJNR Am J Neuroradiol. 2006;27:217–223
  45. Fribourg D, Tang C, Sra P, et al. Incidence of subsequent vertebral fracture after kyphoplasty. Spine. 2004;29:2270–2276discussion 2277
  46. Uppin AA, Hirsch JA, Centenera LV, et al. Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. Radiology. 2003;226:119–124
  47. Legroux-Gerot I, Lormeau C, Boutry N, et al. Long-term follow-up of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Clin Rheumatol. 2004;23:310–317
  48. Keller TS, Kosmopoulos V, Lieberman IH. Vertebroplasty and kyphoplasty affect vertebral motion segment stiffness and stress distributions: a microstructural finite-element study. Spine. 2005;30:1258–1265
  49. Baroud G, Nemes J, Heini P, et al. Load shift of the intervertebral disc after a vertebroplasty: a finite-element study. Eur Spine J. 2003;12:421–426
  50. Baroud G, Heini P, Nemes J, et al. Biomechanical explanation of adjacent fractures following vertebroplasty. Radiology. 2003;229:606–607author reply 607-608
  51. Baroud G, Bohner M. Biomechanical impact of vertebroplasty (Postoperative biomechanics of vertebroplasty). Joint Bone Spine. 2006;73:144–150
  52. Melton LJ, Atkinson EJ, Cooper C, et al. Vertebral fractures predict subsequent fractures. Osteoporos Int. 1999;10:214–221
  53. Ananthakrishnan D, Berven S, Deviren V, et al. The effect on anterior column loading due to different vertebral augmentation techniques. Clin Biomech (Bristol, Avon). 2005;20:25–31
  54. McGraw JK, Lippert JA, Minkus KD, et al. Prospective evaluation of pain relief in 100 patients undergoing percutaneous vertebroplasty: results and follow-up. J Vasc Interv Radiol. 2002;13:883–886
  55. Diamond TH, Champion B, Clark WA. Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am J Med. 2003;114:257–265
  56. Kallmes DF, Schweickert PA, Marx WF, et al. Vertebroplasty in the mid- and upper thoracic spine. AJNR Am J Neuroradiol. 2002;23:1117–1120
  57. Lieberman IH, Dudeney S, Reinhardt MK, et al. Initial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures. Spine. 2001;26:1631–1638
  58. Biafora SJ, Mardjetko SM, Butler JP, et al. Arterial injury following percutaneous vertebral augmentation: a case report. Spine. 2006;31:E84–E87
  59. Grohs JG, Matzner M, Trieb K, et al. Minimal invasive stabilization of osteoporotic vertebral fractures: a prospective nonrandomized comparison of vertebroplasty and balloon kyphoplasty. J Spinal Disord Tech. 2005;18:238–242
  60. Baroud G, Matsushita C, Samara M, et al. Influence of oscillatory mixing on the injectability of three acrylic and two calcium-phosphate bone cements for vertebroplasty. J Biomed Mater Res B Appl Biomater. 2004;68:105–111
  61. Belkoff SM, Molloy S. Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty. Spine. 2003;28:1555–1559
  62. Takemasa R, Yamamoto H. [Bioactive calcium phosphate paste injection for repair of vertebral fracture due to osteoporosis]. Nippon Rinsho. 2002;60(suppl 3):696–703
  63. Takemasa R, Yamamoto H. [Calcium phosphate paste injection for the treatment of vertebral fracture due to osteoporosis]. Clin Calcium. 2001;11:1595–1600
  64. Lim TH, Brebach GT, Renner SM, et al. Biomechanical evaluation of an injectable calcium phosphate cement for vertebroplasty. Spine. 2002;27:1297–1302
  65. Belkoff SM, Mathis JM, Jasper LE. Ex vivo biomechanical comparison of hydroxyapatite and polymethylmethacrylate cements for use with vertebroplasty. AJNR Am J Neuroradiol. 2002;23:1647–1651
  66. Cunin G, Boissonnet H, Petite H, et al. Experimental vertebroplasty using osteoconductive granular material. Spine. 2000;25:1070–1076
  67. Takemasa R. [Vertebroplasty for osteoporotic vertebral compression fractures]. Clin Calcium. 2003;13:1306–1309
  68. Perry A, Mahar A, Massie J, et al. Biomechanical evaluation of kyphoplasty with calcium sulfate cement in a cadaveric osteoporotic vertebral compression fracture model. Spine J. 2005;5:489–493
  69. Baroud G, Martin PL, Cabana F. Ex vivo experiments of a new injection cannula for vertebroplasty. Spine. 2006;31:115–119
  70. Baroud G, Steffen T. A new cannula to ease cement injection during vertebroplasty. Eur Spine J. 2005;14:474–479

PII: S1084-208X(07)00050-X

doi: 10.1053/j.trap.2007.05.010

Techniques in Regional Anesthesia & Pain Management
Volume 11, Issue 3 , Pages 164-170 , July 2007