Techniques in Regional Anesthesia & Pain Management
Volume 13, Issue 1 , Pages 5-8 , January 2009

An introduction to migraine pathophysiology

  • Dyveke Pratt Benoit, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dyveke Pratt Benoit, MD, Department of Neurology, Boston University, 72 East Concord Street, Boston, MA 02118

References 

  1. Shapiro RE. Pathophysiology and genetics of migraine and cluster headache. In:  Levin M editors. Comprehensive Review of Headache Medicine. New York, NY: Oxford University Press; 2008;p. 21–38
  2. Shibata K. Neurophysiology of visual aura in migraine. Brain Nerve. 2007;59:961–970
  3. Silberstein SD. Migraine pathophysiology and its clinical implications. Cephalalgia. 2004;24(suppl 2):2–7
  4. Malick A, Burstein R. Peripheral and central sensitization during migraine. Funct Neurol. 2000;15(suppl 3):28–35
  5. Welch KM, Nagesh V, Aurora SK, et al. Periaqueductal gray matter dysfunction in migraine: Cause or the burden of illness?. Headache. 2001;41:629–637
  6. Moskowitz MA, Bolay H, Dalkara T. Deciphering migraine mechanisms: Clues from familial hemiplegic migraine genotypes. Ann Neurol. 2001;55:276–280
  7. Teive HAG, Kowacs PA, Maranhão Filho P, et al. Leão's cortical spreading depression: from experimental “artifact” to physiological principle. Neurology. 2005;65:1455–1459
  8. Cutrer FM, O'Donnell A, Sanchez del Rio M. Functional neuroimaging: Enhanced understanding of migraine pathophysiology. Neurology. 2000;55(suppl 2):S36–S45
  9. Bussone G. Pathophysiology of migraine. Neurol Sci. 2004;25(suppl 1):s239–s241
  10. Tunis MM, Wolff HG. Studies on headache; long-term observations of the reactivity of the cranial arteries in subjects with vascular headache of the migraine type. AMA Arch Neurol Psychiatry. 1953;70:551–557
  11. Olesen J. Cerebral and extracranial circulatory disturbances in migraine: Pathophysiological implications. Cerebrovasc Brain Metab Rev. 1991;3:1–28
  12. Moskowitz MA. Defining a pathway to discovery from bench to bedside: The trigeminovascular system and sensitization. Headache. 2008;48:688–690
  13. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of migraine. Ann Neurol. 2005;58:698–705
  14. Moskowitz MA. Basic mechanisms in vascular headache. Neurol Clin. 1990;8:801–815
  15. Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: A race against the development of central sensitization. Ann Neurol. 2004;55:27–36
  16. Zhang XC, Strassman AM, Burstein R, et al. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007;322:806–812

PII: S1084-208X(09)00011-1

doi: 10.1053/j.trap.2009.04.002

Techniques in Regional Anesthesia & Pain Management
Volume 13, Issue 1 , Pages 5-8 , January 2009

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