Techniques in Regional Anesthesia & Pain Management
Volume 14, Issue 2 , Pages 42-47, April 2010

Voltage-gated calcium channels and pain

  • Lisa Doan, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Lisa Doan, MD, Department of Anesthesiology, NYU Langone Medical Center, 317 E. 34th St, Ste. 902, New York, NY 10016

Center for Study & Treatment of Pain, Department of Anesthesiology, New York University School of Medicine, New York, New York

Voltage-gated calcium channels have been shown to play a role in the development of chronic pain. Much is known about specific subtypes as well as specific subunits of voltage-gated calcium channels in pain. These channels provide a therapeutic opportunity in managing chronic pain. N-type and T-type voltage-gated calcium channels are the most studied subtypes in regard to pain. The role of the subunit α2δ has also been studied. This article reviews the evidence for the role of these channels in pain.

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PII: S1084-208X(10)00020-0

doi:10.1053/j.trap.2010.03.003

Techniques in Regional Anesthesia & Pain Management
Volume 14, Issue 2 , Pages 42-47, April 2010

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