« Previous
Next »
Techniques in Regional Anesthesia & Pain Management
Volume 14, Issue 2
, Pages 42-47
, April 2010
Voltage-gated calcium channels and pain
References
- Prevalence of chronic pain in a representative sample in the United States. Pain Med. 2008;9:803–812
- . Chronic pain and major depressive disorder in the general population. J Psychiatr Res. 2010;(in press)
- . Structure and regulation of voltage-gated Ca channels. Annu Rev Cell Dev Biol. 2000;16:521–544
- Induction of calcium currents by the expression of the A1-subunit of the dihydropyridine receptor from skeletal muscle. Nature. 1989;340:233–236
- Acceleration of activation and inactivation by the b sununit of the skeletal muscle calcium channel. Nature. 1991;352:159–162
- The roles of the subunits in the function of the calcium channel. Science. 1991;253:1553–1667
- . Calcium channel γ subunits provide insights into the evolution of this gene family. Gene. 2001;280:37–48
- Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit. Neuron. 1992;9:1099–1115
- Neurochemical evidence for the involvement of N-type calcium channels in transmitter secretion from peripheral endings of sensory nerves in Guinea pigs. Neurosci Lett. 1990;114:203–206
- . The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 2000;1:11–21
- . m-opioid-receptor-mediated inhibition of the N-type calcium-channel current. Proc R Soc Lond B. 1991;244:129–135
- Determinants of the G protein-dependent opioid modulation of neuronal calcium channels. Proc Natl Acad Sci U S A. 1996;93:1486–1491
- Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochimie. 1984;23:5087–5090
- Neuronal calcium channel antagonists (Discrimination between calcium channel subtypes using omega-conotoxin from conus Magus venom). Biochimie. 1987;26:2086–2090
- . Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther. 1994;269:1117–1123
- . Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation. Pain. 1997;69:93–100
- . Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Pain. 2001;92:235–246
- . Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons. Brain Res. 1996;18:265–273
- . Effects of substance P on neurones in the dorsal horn of the spinal cord of the cat. Brain Res. 1979;166:273–282
- Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn. Brain Res. 1985;325:294–298
- Analgesic activities of spinal cord substance P antagonists implicate substance P as a neurotransmitter of pain sensation. Brain Res. 1986;385:74–85
- Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats. Brain Res. 1987;403:350–354
- Supression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001;20:2349–2356
- . Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1. Mol Neurobiol. 2002;26:21–44
- Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron. 2004;41:127–138
- Differential role of N-type calcium channel Splice isoforms in pain. J Neurosci. 2007;27:6363–6373
- Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain. Reg Anesth Pain Med. 2000;25:274–278
- Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS. J Am Med Assoc. 2004;291:64–70
- A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. J Pain Symptom Manage. 2006;31:393–406
- Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: Addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain. Pain Med. 2008;9:271–281
- Open-label, multicenter study of combined intrathecal morphine and ziconotide: Addition of morphine in patients receiving ziconotide for severe chronic pain. Pain Med. 2008;9:282–290
- Sympatholysis after neuron-specific, N-type, voltage-sensitive calcium channel blockade: First Demonstration of N-channel function in human. J Cardiovasc Pharmacol. 1997;30:400–403
- Cardiovascular effects of ω-conopeptides in conscious rats: Mechanisms of action. J Cardiovasc Pharmacol. 1992;20:756–764
- The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain. 2002;96:119–127
- . Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur J Pharmacol. 2002;451:279–286
- . Novel pain relief via marine snails. Lancet. 2005;366:439–440
- Cardiovascular and autonomic effects of ω-conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays. Br J Pharmacol. 2000;131:1325–1336
- . CNSB004 (Leconotide) causes Antihyperalgesia without side effects when given intravenously: A comparison with ziconotide in a rat model of diabetic neuropathic pain. Pain Med. 2010;11:262–273
- . Low-voltage-activated (“T-Type”) calcium channels in review. J Bioenerg Biomembr. 2003;35:533–575
- Subthreshold synaptic activation of voltage-gated Ca2+ channels mediates a localized Ca2+ influx into the dendrites of hippocampal pyramidal neurons. J Neurophysiol. 1995;74:1335–1342
- . Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol. 1996;58:329–348
- . Effects of ethosuximide, a T-type Ca2+ channel blocker, on dorsal horn neuronal responses in rats. Eur J Pharmacol. 2001;415:141–149
- Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci. 2007;27:3305–3316
- Up-regulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol. 2008;99:3151–3156
- Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J. 2005;24:315–324
- Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion. Acta Pharmacol Sin. 2006;27:1547–1552
- Attenuated pain responses in mice lacking Cav3.2 T-type channels. Genes Brain Behav. 2007;6:425–431
- Attenuated neuropathic pain in Cav3.1 null mice. Mol Cells. 2008;25:242–246
- . Thalamic control of visceral nociception mediated by T-type Ca2+ channels. Science. 2003;302:117–119
- Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain. 2003;105:159–168
- . Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain. 2004;109:150–161
- . The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. Eur J Pharmacol. 2005;521:79–85
- . Ethosuximide: From bench to bedside. CNS Drug Res. 2007;13:224–239
- Knockdown of L calcium channel subtypes: Differential effects in neuropathic pain. J Neurosci. 2010;30:1073–1085
- . Localization of Ca2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. J Neurosci. 1998;18:6319–6330
- Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience. 2009;160:165–173
- Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel α1 subunits in the dorsal horn of spinal cord in mice. Brain Res. 2004;1024:122–129
- Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel. Proc Natl Acad Sci USA. 2000;97:6132–6137
- Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochimie. 1998;37:15353–15362
- The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007;25:3561–3569
- . Antiepileptics from gamma-aminobutyric acid. Arzneim Forsch. 1994;44:261–266
- Chemical development of CI-1008, an enantiomerically pure anticonvulsant. Org Proc Res Dev. 1997;1:26–38
- . GABAergic mechanisms in the pathogenesis of epilepsy. Br J Clin Pharmacol. 1989;27:3S–11S
- The novel anticonvulsant drug, gabapentin (Neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem. 1996;271:5768–5776
- A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 1998;29:231–246
- . Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain. 1996;12:56–58
- . Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil. 1997;78:98–105
- . Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth Pain Med. 1997;22:249–256
- Human neuronal voltage-dependent calcium channels: Studies on subunit structure and role in channel assembly. Neuropharmacology. 1993;32:1089–1102
- Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neurons. Neurosci Lett. 2001;311:137–141
- . Calcium channel α2δ subunits—Structure and gabapentin binding. Mol Pharmacol. 2001;59:1243–1248
- Upregulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci. 2001;21:1868–1875
- Injury type-specific calcium channel α2δ-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther. 2002;303:1199–1205
- Spinal dorsal horn calcium channel α2δ -1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. J Neurosci. 2004;24:8494–8499
- Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation. Pain. 2006;125:20–31
- Evaluation of gabapentin and S-(+)-isobutyl GABA in a rat model of postoperative pain. J Pharmacol Exp Ther. 1997;282:1242–1246
- Gabapentin (Neurontin) and S-(+)-3-isobutyl GABA represent a novel class of selective anti-hyperalgesic agents. Br J Pharmacol. 1997;121:1513–1522
- Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin. Proc Natl Acad Sci USA. 2008;105:3628–3633
- The increased trafficking of the calcium channel subunit α2δ-1 to presynaptic terminals in neuropathic pain is inhibited by the a2d ligand Pregabalin. J Neurosci. 2009;29:4076–4088
- . Down-regulation of N-type voltage-activated channels by gabapentin. Cell Mol Neurobiol. 2002;22:185–190
- . Gabapentin may inhibit synaptic transmission in the mouse spinal cord dorsal horn through a preferential block of P/Q-type calcium channels. Neuropharmacology. 2004;46:743–749
- Pharmacologic management of neuropathic pain: Evidence-based recommendations. Pain. 2007;132:237–251
- Pregabalin for the treatment of fibromyalgia syndrome: Results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2005;52:1264–1273
- A randomized, double-blind, placebo-controlled, phase III trial of Pregabalin in the treatment of patients with fibromyalgia. J Rheumatol. 2008;35:502–514
PII: S1084-208X(10)00020-0
doi: 10.1053/j.trap.2010.03.003
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Techniques in Regional Anesthesia & Pain Management
Volume 14, Issue 2
, Pages 42-47
, April 2010
